Understanding Alzheimer’s disease mechanisms
Alzheimer’s treatments have focused on blocking the fibrilisation of the beta-amyloid1-40 (Aβ) peptide, as research suggests that this is the main neurotoxic event in the disease progression1.
Yet the subtle cascade of effects the neurotoxic peptides and subsequent neuritic plaques have on neuronal cells has been elusive, requiring much time, labor and expense to determine.
With this need in mind, Cellomics (Thermo Fisher Scientific) created the Neuronal Profiling BioApplication to efficiently calculate morphological features of primary neurons, mixed cultures, and neuronal cells lines in response to toxins or therapeutic compound administration.
The Neuronal Profiling BioApplication achieves this level of information allowing the most detailed data possible from neuronal cultures.